Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
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منابع مشابه
Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, we show early signs of aging in SNpc, which are more evident than in ventral tegmental area (VTA), a region adjacent to SNpc but less affected ...
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New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in ...
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In Parkinson's disease, progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SN) leads to debilitating motor dysfunction. One current therapy aims at exogenous cellular replacement of dopaminergic function by transplanting fetal midbrain cells into the striatum, the main projection area of the SN. However, results using this approach have shown variable success. It ha...
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REFERENCES 1. BALY, F. A., History ofSouthport, Southport, Angus Downie, 1955, p. 37. 2. BmuxmHourr, J., An Essay on the Bite of a Mad Dog, London, R. Baldwin, 1783. 3. British Museum, Add. MS. 36876. 4. FoHRGLL, J., 'The Case of a Hydrophobia', in: Medical Observations and Enquiries, 2nd ed., 1779, vol. 5, p. 195. 5. HBYSHAM, J., Dissertatio Medica de Rabie Canina, Edinburgh, 1777. Information...
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The substantia nigra (SN) is known to be involved in the memorization of several conditioned responses. To investigate the role of the SN in fear conditioning consolidation this neural site was subjected to fully reversible tetrodotoxin (TTX) inactivation during consolidation in adult male Wistar rats which had undergone fear training to acoustic CS and context. TTX was stereotaxically administ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0062456